ESTABLISHING SERUM REFERENCE RANGES OF ANTIHYPERTENSIVE DRUGS

Objective: Therapeutic drug monitoring (TDM) is the measurement of serum concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used evaluate antihypertensive response. However, approximately 50 % hypertensive patients treated by lifestyle changes drugs fail achieve control. Serum concentration could be useful select optimal in adjusted doses identify non-adherence. Implementation TDM clinical routine for depends on established reference ranges. Design method: Commonly were identified based prescription data. The authors performed a review authoritative literature reported calculated expected from previously pharmacokinetic parameters with commonly prescribed daily doses. Finally, samples undergoing treatment measured. Results: ranges 24 frequently results three approaches are shown table.Conclusions: concentrations, interpreted light ranges, together other data, may help non-adherent tailor individual when deviant responses appear, line concept personalized medicine.